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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: regulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear developmentWe found that the downregulation of Notch1 in Lgr5 cells from embryonic day (E) 14.5 to E18.5 can driveLgr5 cells to re-enter the cell cycle and differentiate into extra HCs, whereas the upregulation of Notch1No effect was observed on the upregulation or downregulation of Notch1 in Lgr5 cells from E10.5 to E14.5We concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependent

Keywords： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: More than 60% of T-ALL patients carry NOTCH1 gene mutations, leading to abnormal expression ofHDAC inhibitor, exerts an antitumor effect on T-ALL cell lines and primary cells including an anti-NOTCH1In particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellularform of NOTCH1 (NICD1) as well as MYC, partly through their ubiquitination and degradation by the proteasomethe effectiveness and safety of chidamide in the treatment of T-ALL patients, including those with NOTCH1

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract: regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notchand Atoh1.

Keywords： utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

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Parametric equations for notch stress concentration factors of rib–deck welds under bending loading

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3,   Pages 595-608 doi: 10.1007/s11709-021-0720-1

Abstract: The effective notch stress approach for evaluating the fatigue strength of rib–deck welds requires notchFirst, we developed a model for investigating the effective notch stress in rib–deck welds.parametric analysis to investigate the effects of multiple geometric parameters of a rib–deck weld on the notchstepwise regression analysis was performed to obtain the optimal regression functions for predicting the notchThe notch stress concentration factors estimated from the developed formulas show agree well with the

Keywords： notch stress concentration factor     rib–deck weld     parametric analysis     regression analysis     parametric    

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: regenerative capacity because of the active participation of various signaling pathways, including Wnt and NotchThe Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multipleIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationThis review presents the current understanding of the Wnt and Notch signaling pathways in the auditoryand discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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Crack propagation with different radius local random damage based on peridynamic theory

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1238-1248 doi: 10.1007/s11709-021-0695-y

Abstract: This study implements the peridynamic theory by subjecting bilateral notch cracked specimens to the conditions

Keywords： peridynamics     stochastic damage     bilateral notch crack    

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The Analyzing Method for Fatigue Life of Aircraft Structures Under Corrosive Environment

Mu Zhitao

Strategic Study of CAE 2002, Volume 4, Issue 3,   Pages 68-72

Abstract: environment characteristics and corrosion depth distribution law of the naval aircraft structures fatigue notch

Keywords： aircraft structure     fatigue life     corrosive environment     fatigue notch factor    

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Structural parameter design method for a fast-steering mirror based on a closed-loop bandwidth

Guozhen CHEN, Pinkuan LIU, Han DING

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 1,   Pages 55-65 doi: 10.1007/s11465-019-0545-y

Abstract: In accordance with the transfer function, the notch filter and proportional-integral (PI) feedback controller

Keywords： fast-steering mirror     structural parameter     PI controller     bandwidth     notch filter    

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Mechanical responses of pristine and defective hexagonal boron-nitride nanosheets: A molecular dynamics investigation

Mohammad SALAVATI, Arvin MOJAHEDIN, Ali Hossein Nezhad SHIRAZI

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 623-631 doi: 10.1007/s11709-020-0616-5

Abstract: In this work we conducted classical molecular dynamics (MD) simulation to investigate the mechanical characteristics and failure mechanism of hexagonal boron-nitride (h-BN) nanosheets. Pristine and defective structure of h-BN nanosheets were considered under the uniaxial tensile loadings at various temperatures. The defective structure contains three types of the most common initial defects in engineering materials that are known as cracks, notches (with various length/size), and point vacancy defects (with a wide range of concentration). MD simulation results demonstrate a high load-bearing capacity of extremely defective (amorphized) h-BN nanosheets. Our results also reveal that the tensile strength decline by increasing the defect content and temperature as well. Our MD results provide a comprehensive and useful vision concerning the mechanical properties of h-BN nanosheets with/without defects, which is very critical for the designing of nanodevices exploiting the exceptional physics of h-BN.

Keywords： hexagonal boron-nitride     mechanical properties     crack     notch     point defects     molecular dynamics    

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Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Strategic Study of CAE 2007, Volume 9, Issue 5,   Pages 91-94

Abstract:

Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.the monotonicity of predicted value and its variation tendency,  applicability criterion of GM(1,1) is brought forward.

Keywords： fire forecast     GM(1     1)     rate of the fire injured    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1,and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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Numerical simulation of the rockburst processes of a circular tunnel at different dilation angles

Wang Xuebin,Pan Yishan,Zhang Zhihui

Strategic Study of CAE 2010, Volume 12, Issue 2,   Pages 40-46

Abstract: an increase of the dilation angle, the shear band becomes wider; the dog-ear or V-shaped rockburst notch

Keywords： dilation angle     circular tunnel     rockburst     shear band     V-shaped notch     shear strain     volumetric strain    

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geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Strategic Study of CAE 2011, Volume 13, Issue 10,   Pages 13-18

Abstract: According to this guidance, such giant oilfield JX1-1 was discovered with 150 million reserves in the

Keywords： Bohai Liaodong zone     JX1-1     geological recognition     large oilfield    

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Federated unsupervised representation learning Research Article

Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 8,   Pages 1181-1193 doi: 10.1631/FITEE.2200268

Abstract: FURL poses two new challenges: (1) data distribution shift (non-independent and identically distributed

Keywords： Federated learning     Unsupervised learning     Representation learning     Contrastive learning    

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Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Strategic Study of CAE 2012, Volume 14, Issue 7,   Pages 98-102

Abstract: text-align: justify;">Aiming at the problem of modeling for non-equidistant sequence, the non-equidistant GM(1,1The results showed that the form of non equidistant GM(1,1) power model was more flexible than the traditionalBoth non equidistant GM(1,1) model and Grey Verhulst model were the special cases of non equidistantGM(1,1) power model.shows modeling accuracy in traditional modeling, which was significantly improved by non equidistant GM(1,1

Keywords： grey system     non-equidistant sequence     GM(1     1) power model     parameter optimization    

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Title Author Date Type Operation

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

Parametric equations for notch stress concentration factors of rib–deck welds under bending loading

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Crack propagation with different radius local random damage based on peridynamic theory

Journal Article

The Analyzing Method for Fatigue Life of Aircraft Structures Under Corrosive Environment

Mu Zhitao

Journal Article

Structural parameter design method for a fast-steering mirror based on a closed-loop bandwidth

Guozhen CHEN, Pinkuan LIU, Han DING

Journal Article

Mechanical responses of pristine and defective hexagonal boron-nitride nanosheets: A molecular dynamics investigation

Mohammad SALAVATI, Arvin MOJAHEDIN, Ali Hossein Nezhad SHIRAZI

Journal Article

Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Numerical simulation of the rockburst processes of a circular tunnel at different dilation angles

Wang Xuebin,Pan Yishan,Zhang Zhihui

Journal Article

geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Journal Article

Federated unsupervised representation learning

Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn

Journal Article

Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Journal Article